An overarching goal of the TBRU is to develop and implement a systematic and multidisciplinary approach towards furthering scientific understanding of the epidemiology, microbiology, immunology and host genetics of MTB infection and disease in populations with a high prevalence of disease. The Household Contact Study provided a framework for assessing the risk of infection with MTB and of developing active TB, for evaluating innovative methods for prevention, diagnosis and treatment, and for assessing the burden of disease in a community with a high prevalence of TB.
Objectives of Study:
- To determine critical host factors associated with primary MTB infection, re-infection, reactivation, and progression of clinical disease
- To identify and track individual strains of MTB through Ugandan households and local community
