Pilot Immunology Study
Status: ACTIVE
Duration: October 2002-Present
PIs: W. Henry Boom, MD, CWRU; Harriet Mayanja-Kizza, MBChB, M.Med., PhD, Uganda-CWRU Research Collaboration
Developmental Immunology Studies to Assess ex vivo Regulation of Host Cell-mediated and Humoral Immune Responses during Short Course Anti-TB Treatment of HIV-infected and HIV-non-infected Adults with Initial Episodes of Culture Confirmed Pulmonary Tuberculosis
Bronchoscopy Study - DMID 16-0063
Status: ACTIVE
Duration: 2022 - Present
PIs: W. Henry Boom, MD, CWRU; Harriet Mayanja-Kizza, M.B.Ch.B., M.Med., PhD., Uganda-CWRU Research Collaboration
Study of immunologic and microbiologic parameters of TB infection in lungs of adult household contacts.
Long-term TB Resister Study RV19
Status: ACTIVE
Duration: 2019 - Current
PIs: W. Henry Boom, MD and Catherine Stein, PhD, CWRU; Harriet Mayanja-Kizza, MBChB, MMed, PhD, Uganda-CWRU Research Collaboration.
Long-term resistance to latent Mycobacterium tuberculosis infection (RV-19).
Adaptive Immunity to Mtb
Status: ACTIVE
Duration: 2021 - Present
PIs: Christine Lancioni, MD, OHSU; Catherine Stein, PhD, CWRU; Ezekiel Mupere, MBChB, PhD, Uganda-CWRU Research Collaboration
Adaptive Immunity to Mtb-infection and TB Disease Among Young Ugandan Children (PA21).
Gates Grand Challenge.
Status: COMPLETED
Duration:2013-2015
PIs:Willem Hanekom, University of Cape Town
GC6-2013: Systems biology to identify signatures of risk of TB disease in Gates Global Challenge 6-74 cohorts.
Kawempe Community Health Study
Status: COMPLETED
Duration:2002-2017
PIs:W. Henry Boom, MD, CWRU; Harriet Mayanja-Kizza, MBChB, MMed., PhD, Uganda-CWRU Research Collaboration
DMID Protocol Number: 01-005
Viti Inc.
Status: COMPLETED
Duration:September 2014 - March 2015
PIs:Deborah A. Lewinsohn, M.D., Viti Inc.
DMID Protocol Number: 13-0018
AZD 5847 Early Bactericidal Activity - DMID 11-0006
Status: COMPLETED
Duration:2012-2015
PIs:W. Henry Boom, MD John L. Johnson, MD Catherine Stein, PhD Charles Bark, MD
Randomized, Open Label, Multiple Dose Phase 2a Study of the Early Bactericidal Activity of AZD5847 in Adults with Pulmonary Tuberculosis
Isoniazid - BCG - DMID 07-0083.
Status: COMPLETED
Duration:2009-2015
PIs:W. Henry Boom, MD John L. Johnson, MD Catherine Stein, PhD Charles Bark, MD
Phase I Study of Whether Preclearance of Latent M. tuberculosis (MTB) Infection with Isoniazid (INH) Enhances Specific Immune Response to MTB Following Subsequent BCG Revaccination in Healthy, HIV-uninfected, Tuberculin Skin Test Positive Adults
Childhood Acute Illness Trial
Status: COMPLETED
Duration:2021 - 2023
PIs: Robert Bandsma, Wieger Voskuijl, and James Berkley, University of Oxford; Ezekiel Mupere, MBChB, MMed, PhD, Uganda-CWRU Research Collaboration; Christina Lancioni, MD, Oregon Health & Science University; Johnstone Thitiri, KEMRI/Kenya, Caroline Ogwang, KEMRI/Kenya; Emmie Mbale, Malawi; Mohammod Jobayer, Bangladesh, Robert Bandsma, Canada
Pancreatic Enzymes and Bile Acids: A Non-Antibiotic Approach to Treat Intestinal Dysbiosis in Acutely Ill Severely Malnourished Children (CHAIN 2.0/PB-SAM).